Ayman Khalil, a 34-year-old father of three in Rafah, clutched his children’s hands as airstrikes shook Gaza on Friday, the start of Israel’s “Operation Gideon’s Chariots.” “They’re screaming for food, but we have nothing,” he said, his eyes hollow from days without sleep. The Israeli military’s major new offensive, launched the same day U.S. President Donald Trump departed the Middle East without a ceasefire agreement, has plunged Gaza deeper into despair. Over 250 Palestinians have died in the past week, Gaza health officials report, while families on both sides of the conflict grapple with fear and loss.

The Israeli Defense Forces (IDF) struck 130 “terror targets” in Gaza over two days, targeting Hamas infrastructure. Announced Friday night, the operation aims to free hostages and defeat Hamas, with Prime Minister Benjamin Netanyahu vowing to hold seized territory. “Our children deserve safety,” he said, addressing Israelis mourning the 1,200 killed in Hamas’s October 7, 2023, attack that sparked the war and left 250 hostages. In Gaza, where 53,000 have died and 90% of 2.3 million residents are displaced, the offensive intensifies a humanitarian crisis marked by a two-month aid blockade.

Trump’s Middle East tour—visiting Saudi Arabia, Qatar, and the UAE but skipping Israel—ended without hope for peace. In Doha, he spoke of Gaza’s suffering, saying, “Mothers and kids are starving; it’s a tragedy,” and suggested a “freedom zone” without specifics. His team secured the release of U.S.-Israeli hostage Edan Alexander this week, but ceasefire talks collapsed as bombs fell. For Gaza’s residents, like Umm Mohammed al-Tatari, a 57-year-old grandmother, the timing feels like betrayal. “I lost my neighbor, my home,” she wept, sifting through rubble. “Where is the world?”

In Israel, families of the 58 remaining hostages live in anguish. Rachel Cohen, a mother from Jerusalem, stood at a rally, her voice breaking: “My son’s been gone 589 days. Every explosion could take him from me.” The conflict’s toll is relentless: Gaza’s hospitals, without fuel, turn away bleeding children; Israeli communities near the border huddle in shelters as Hamas rockets fly. The U.N.’s António Guterres warned that more fighting risks “unimaginable” civilian deaths, urging both sides to stop. Yet, with reservists mobilized, Israel signals a long campaign.

The war’s roots trace to Hamas’s 2023 attack, but its human cost defines today. In Gaza, families like Khalil’s sleep in tents, scavenging for scraps. “My daughter asks why we can’t go home,” he said. “I don’t know how to answer.” In Israel, parents like Cohen cling to photos of their missing, torn between hope and dread. International voices, including France’s Foreign Minister Jean-Noël Barrot, call Israel’s tactics “unacceptable,” citing humanitarian law. Aid groups warn of a policy to displace Gazans, pointing to Netanyahu’s talk of encouraging emigration through destruction—a charge Israel denies.

Reactions pour out in protests and prayers. Gazans share videos of shattered schools, pleading for aid. In Tel Aviv, crowds chant “Bring Them Home,” their signs swaying in the wind. Globally, thousands march in cities like Paris and Chicago, demanding peace. Social media amplifies the pain: a Gaza teen’s post reads, “I just want to live”; an Israeli father writes, “I need my daughter back.” The war strains U.S.-Israel ties, with Trump’s Gulf focus frustrating Netanyahu, who faces pressure to free hostages while battling Hamas.

The consequences touch every life. Gaza’s neighborhoods lie in ruins, its people starving. Israel’s economy falters under military costs, and Netanyahu’s support frays. The U.S. risks global backlash if the crisis grows. Without a ceasefire, regional escalation looms, with groups like Hezbollah watching closely. For Khalil, Cohen, and millions, the future is a daily struggle to survive.

What’s next? Israel’s troop buildup suggests months of fighting, while Hamas rejects talks, accusing Israel of “slaughter.” Doha mediators push for dialogue, but hope fades with each bomb. In Gaza, al-Tatari dreams of rebuilding; in Jerusalem, Cohen prays for her son’s voice. As the world grapples with their pain, one question lingers: can humanity prevail over this cycle of loss?